December 22, 2023
Unlocking the Secrets of Aging: Breakthrough Study Reveals Notch3 Pathway’s Key Role in Vascular Health

Understanding Vascular Aging and Neurodegeneration: Notch3 Signaling Pathway’s Crucial Role Unveiled in New Study A groundbreaking study by Northwestern Medicine, published in the Journal of Clinical Investigation, sheds light on the intricate relationship between vascular aging, neurodegeneration, and CADASIL. This research, led by Dr. Luisa Iruela-Arispe, offers valuable insights into the aging process of brain

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Finding a cure

Led by the University of Washington Medicine Neurosciences Institute, a team of medical geneticists is researching the Notch3 gene to learn how mutations in Notch3 lead to stroke and dementia. Their approach uses gene sequencers and a cutting-edge technique called variant interpretation. This technique enables them to analyze gene mutations and assess the impact of those mutations faster than ever before.

See the current research

Support Our Work

At the CADASIL Eradication Project, our mission is to support genomic research that leads to treatments for CADASIL and related small vessel diseases. Your donations help!

Hire additional lab researchers to analyze Notch3

Pay for additional lab materials for analyzing Notch3 mutations

Support outreach and collaboration with other rare disease researchers

Every $75,000 we raise doubles the pace for analyzing Notch3 and getting us closer to a cure. Donate Today

A Team
you can trust

Dr. Suman Jayadev

Suman Jayadev, M.D., is a board-certified neurologist at UW...

James Osborne

James founded the CADASIL Eradication Project after his mother,...

Dr. Lea Starita

Dr. Lea Starita is a Research Assistant Professor in...

Dr. Adam Samuel Gordon

Dr. Gordon is an Assistant Professor of Pharmacology at...

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December 22, 2023
Unlocking the Secrets of Aging: Breakthrough Study Reveals Notch3 Pathway’s Key Role in Vascular Health

Understanding Vascular Aging and Neurodegeneration: Notch3 Signaling Pathway’s Crucial Role Unveiled in New Study A groundbreaking study by Northwestern Medicine, published in the Journal of Clinical Investigation, sheds light on the intricate relationship between...
November 14, 2023
Introducing CADASIL Helper: The First AI Chat Bot Focused on CADASIL

We are thrilled to announce the launch of CADASIL Helper, the first AI chat bot specifically tailored to assist those seeking information and guidance about CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and...
November 9, 2023
Hypertension (High Blood Pressure) and CADASIL

For CADASIL patients, certain antihypertensive medications might be more beneficial in improving microvascular function than others.

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In Loving Memory

The CADASIL Eradication Project was formed in memory of Dianne Dickson, who died from CADASIL in 2008. Dianne was a talented singer and award-winning Sweet Adelines director who dedicated her time and passion to helping thousands of New England women discover lifelong sisterhood and joy through music.